Splenectomy refers to the surgical removal of the spleen, a large organ located in the upper left part of the stomach that contains macrophages (specialized cells that fight against the foreign bodies). The procedure is indicated in splenomegaly, a condition of enlarged spleen. Laparoscopic splenectomy is performed under general anesthesia. Small incisions are made on the abdomen and a laparoscope (an instrument with a tiny camera and a light at the end) is inserted through one of the incisions. Miniature surgical instruments are introduced through the other incisions.